Xavier Hernandez Alias – Serrano's lab

Translational adaptation of human viruses to the tissues they infect

Xavier Hernandez Alias publication May 20, 2021 May 20, 2021

Abstract: “Viruses need to hijack the translational machinery of the host cell for a productive infection to happen. However, given the dynamic landscape of tRNA pools among tissues, it is unclear whether different viruses infecting different tissues have adapted their codon usage toward their tropism. Here, we collect the coding …

Translational efficiency across healthy and tumor tissues is proliferation-related

Xavier Hernandez Alias publication March 10, 2020 March 10, 2020

Abstract: Different tissues express genes with particular codon usage and anticodon tRNA repertoires. However, the codon–anticodon co‐adaptation in humans is not completely understood, nor is its effect on tissue‐specific protein levels. Here, we first validated the accuracy of small RNA‐seq for tRNA quantification across five human cell lines. We then …