I am a PhD student co-supervised by Luis Serrano and Martin Schaefer (Schaefer lab, at the European Institute of Oncology in Milan). My research interest is to unravel the intricate mechanisms that link genotype and perturbations to specific phenotypes, such as diseases, which is essential to develop accurate predictive tests and effective therapies. In particular, my project aims to elucidate the role of changes in tRNA levels, modifications and aminoacylation on the regulation of translation across different conditions and tissues. Using a systems biology approach, we intend to shed light on the underlying mechanisms driving the dynamical adaptation between codon usage and tRNAomes.
Here the link to the defended PhD Thesis.
2018-2023: PhD Student at the Centre for Genomic Regulation, Systems and Synthetic Biology Programme.
2016-2018: Biology MSc (Major in Systems Biology) at the ETH Zürich.
2012-2016: Biochemistry BSc at the Universitat de Barcelona.
2023. Using protein-per-mRNA differences among human tissues in codon optimization.  Genome Biol 24(1):34,
2023. Single-read tRNA-seq analysis reveals coordination of tRNA modification and aminoacylation and fragmentation.  Nucleic Acids Res 51(3):e17,
2021. Translational efficiency across healthy and tumor tissues is proliferation-related.  Mol Syst Biol 17(3):e10097,
2021. Translational adaptation of human viruses to the tissues they infect.  Cell Rep 34(11):108872,
2021. Silencing of SRRM4 suppresses microexon inclusion and promotes tumor growth across cancers.  PLoS Biol 19(2):e3001138,
2021. Cysteine and Folate Metabolism Are Targetable Vulnerabilities of Metastatic Colorectal Cancer.  Cancers (Basel) 13.,
2020. From research to rapid response: mass COVID-19 testing by volunteers at the Centre for Genomic Regulation.  F1000Res 9:1336,
2020. In silico mutagenesis of human ACE2 with S protein and translational efficiency explain SARS-CoV-2 infectivity in different species.  PLoS Comput Biol 16(12):e1008450,
2020. Mutation bias within oncogene families is related to proliferation-specific codon usage.  Proc Natl Acad Sci U S A 117(48):30848-30856,
2020. Translational efficiency across healthy and tumor tissues is proliferation-related.  Mol Syst Biol 16(3):e9275,
Publication list retrieved from NCBI using ImpactPubs.