I am a PhD student co-supervised by Luis Serrano and Martin Schaefer (Schaefer lab, at the European Institute of Oncology in Milan). My research interest is to unravel the intricate mechanisms that link genotype and perturbations to specific phenotypes, such as diseases, which is essential to develop accurate predictive tests and effective therapies. In particular, my project aims to elucidate the role of changes in tRNA levels, modifications and aminoacylation on the regulation of translation across different conditions and tissues. Using a systems biology approach, we intend to shed light on the underlying mechanisms driving the dynamical adaptation between codon usage and tRNAomes.

Here the link to the defended PhD Thesis.

Background

2018-2023: PhD Student at the Centre for Genomic Regulation, Systems and Synthetic Biology Programme.
2016-2018: Biology MSc (Major in Systems Biology) at the ETH Zürich.
2012-2016: Biochemistry BSc at the Universitat de Barcelona.

Publications

Hernandez-Alias X; Benisty H; Radusky LG; Serrano L; Schaefer MH, 2023. Using protein-per-mRNA differences among human tissues in codon optimization.  Genome Biol 24(1):34

Hernandez-Alias X; Katanski CD; Zhang W; Assari M; Watkins CP; Schaefer MH; Serrano L; Pan T, 2023. Single-read tRNA-seq analysis reveals coordination of tRNA modification and aminoacylation and fragmentation.  Nucleic Acids Res 51(3):e17

Hernandez-Alias X; Benisty H; Schaefer MH; Serrano L, 2021. Translational efficiency across healthy and tumor tissues is proliferation-related.  Mol Syst Biol 17(3):e10097

Hernandez-Alias X; Benisty H; Schaefer MH; Serrano L, 2021. Translational adaptation of human viruses to the tissues they infect.  Cell Rep 34(11):108872

Head SA; Hernandez-Alias X; Yang JS; Ciampi L; Beltran-Sastre V; Torres-Méndez A; Irimia M; Schaefer MH; Serrano L, 2021. Silencing of SRRM4 suppresses microexon inclusion and promotes tumor growth across cancers.  PLoS Biol 19(2):e3001138

Tarragó-Celada J; Foguet C; Tarrado-Castellarnau M; Marin S; Hernández-Alias X; Perarnau J; Morrish F; Hockenbery D; Gomis RR; Ruppin E; Yuneva M; Atauri P; Cascante M, 2021. Cysteine and Folate Metabolism Are Targetable Vulnerabilities of Metastatic Colorectal Cancer.  Cancers (Basel) 13.

Ghose R; Aranguren-Ibáñez Á; Arecco N; Balboa D; Bataller M; Beltran S; Benisty H; Bénard A; Bernardo E; Carbonell Sala S; Casals E; Ciampi L; Condemi L; Corvó A; Cosín-Tomás M; Cuenca-Ardura M; Duran Serrano JM; Espejo Díaz MI; Fernandez Callejo M; Gañez-Zapater A; Garcia-Castellanos R; Garrido R; Henkin G; Hermoso Pulido T; Hernandez-Alias X; Herrero Vicente J; Ingham M; Lim WM; Llonch S; Marmesat Bertoli E; Miguel-Escalada I; Montero-Blay A; Navarrete Hernández C; Neguembor MV; Ní Chárthaigh RA; Pardo-Lorente N; Pascual-Reguant L; Pérez-Lluch S; Perza R; Pesaresi M; Picó Amador D; Pifarré P; Piscia D; Plana-Carmona M; Ponomarenko J; Radusky L; Rivero E; Rogalska M; Torcal Garcia G; Wojnacki J, 2020. From research to rapid response: mass COVID-19 testing by volunteers at the Centre for Genomic Regulation.  F1000Res 9:1336

Delgado Blanco J; Hernandez-Alias X; Cianferoni D; Serrano L, 2020. In silico mutagenesis of human ACE2 with S protein and translational efficiency explain SARS-CoV-2 infectivity in different species.  PLoS Comput Biol 16(12):e1008450

Benisty H; Weber M; Hernandez-Alias X; Schaefer MH; Serrano L, 2020. Mutation bias within oncogene families is related to proliferation-specific codon usage.  Proc Natl Acad Sci U S A 117(48):30848-30856

Hernandez-Alias X; Benisty H; Schaefer MH; Serrano L, 2020. Translational efficiency across healthy and tumor tissues is proliferation-related.  Mol Syst Biol 16(3):e9275

Publication list retrieved from NCBI using ImpactPubs