My project aims to understand the role of microexons Alternative Splicing in the retina, to elucidate its molecular function at the molecular and organismal level and how this process is disrupted in disease. The combination between in vitro, in vivo and bioinformatic approaches offers the opportunity to study from multiple angles the physiologic relevance of microexons, particularly those impacting cilium-related proteins. This work will yield insights into an unexplored mechanism of gene regulation and potentially elucidate new nodes of dysregulated retinal and neurological diseases.