In 2020, I joined Prof. Dr. Luis Serrano’s Lab as a post-doctoral researcher. Since then, I have opened a new line of research to apply all the knowledge developed in systems biology for the design of new pulmonary therapies based on the use of Mycoplasma pnuemoniae for infectious and non-infectious diseases, such as cancer or idiopatic fibrosis. We combine the interesting properties of M. pneumoniae (mainly related with the lack of extracelullar wall) with protein design to locally modulate the immune system of the lung.
Background
2020-Currently: Senior Post-doctoral researcher – Systems Biology – Center for Genomic Regulation (CRG) (Barcelona, Spain)
2019-2020: Research technician – Center for Genomic Regulation (CRG) – Institute of Agrobiotechnology -CSIC (Pamplona, Spain)
2014-2018: PhD in Biotechnology – Public University of Navarra (UPNa) – Institute of Agrobiotechnology -CSIC (Pamplona, Spain)
2012-2013: MSc Microbiology – Autonomous University of Madrid (UAM) (Madrid, Spain)
2006-2012: BSc Veterinary Medicine – Complutense University of Madrid (UCM) (Madrid, Spain)
Scientific articles
– Mazzolini R*, Rodríguez-Arce I*, Fernández-Barat L, Piñero-Lambea C, Garrido V, Rebollada-Merino A et al. Engineered live bacteria suppress Pseudomonas aeruginosa lung infection in mouse and dissolve biofilm in endotracheal tubes from patients. Nature Biotech, 2023. DOI: 10.1038/s41587-022-01584-9.
– Montero-Blay A*, Delgado Blanco J*, Rodríguez-Arce I*, Lastrucci C, Piñero-Lambea C Lluc-Senar M et al. Bacterial expression of a designed single-chain IL-10 prevents severe lung inflammation. Mol Syst Bio, 2023. In press. DOI: 10.15252/msb.202211037.
– Garrido V*, Piñero-Lambea C*, Rodriguez-Arce I, Paetzold B, Ferrar T, Weber M, Garcia-Ramallo E, Gallo C, Collantes M, Peñuelas I, Serrano L, Grilló MJ, Lluch-Senar M. Engineering a genome-reduced bacterium to eliminate Staphylococcus aureus biofilms in vivo. Mol Syst Biol. DOI: 10.15252/msb.202010145.
– Rodríguez-Arce I, Morales X, Ariz M, Euba B, López-López N, Esparza M, Hood DW, Leiva J, Ortíz-de-Solórzano C, Garmendia J. Development and multimodal characterization of an elastase-induced emphysema mouse disease model for the COPD frequent bacterial exacerbator phenotype. Virulence. 2021. DOI: 10.1080/21505594.2021.1937883.
– Euba B, López-López N, Rodríguez-Arce I, Fernández-Calvet A, Barberán M, Caturla N, Martí S, Díez-Martínez R, Garmendia J. Resveratrol therapeutics combines both antimicrobial and immunomodulatory properties against respiratory infection by nontypeable Haemophilus influenzae. Sci Rep. 2017. DOI: 10.1038/s41598-017-13034-7.
– Rodríguez-Arce I*, Al-Jubair T*, Euba B*, Fernández-Calvet A, Gil-Campillo C, Martí S, Törnroth-Horsefield S, Riesbeck K, Garmendia J. Moonlighting of Haemophilus influenzae heme acquisition systems contributes to the host airway-pathogen interplay in a coordinated manner. Virulence. 2019. DOI: 10.1080/21505594.2019.1596506.
– Fernández-Calvet A, Rodríguez-Arce I, Almagro G, Moleres J, Euba B, Caballero L, Martí S, Ramos-Vivas J, Bartholomew TL, Morales X, Ortíz-de-Solórzano C, Yuste JE, Bengoechea JA, Conde-Álvarez R, Garmendia J. Modulation of Haemophilus influenzae interaction with hydrophobic molecules by the VacJ/MlaA lipoprotein impacts strongly on its interplay with the airways. Sci Rep. 2018. DOI: 10.1038/s41598-018-25232-y.
– Moleres J, Fernández-Calvet A, Ehrlich RL, Martí S, Pérez-Regidor L, Euba B, Rodríguez-Arce I, Balashov S, Cuevas E, Liñares J, Ardanuy C, Martín-Santamaría S, Ehrlich GD, Mell JC, Garmendia J. Antagonistic Pleiotropy in the Bifunctional Surface Protein FadL (OmpP1) during Adaptation of Haemophilus influenzae to Chronic Lung Infection Associated with Chronic Obstructive Pulmonary Disease. mBio. DOI: 10.1128/mBio.01176-18.
– Rodríguez-Arce I, Martí S, Euba B, Fernández-Calvet A, Moleres J, López-López N, Barberán M, Ramos-Vivas J, Tubau F, Losa C, Ardanuy C, Leiva J, Yuste JE, Garmendia J. Inactivation of the Thymidylate Synthase thyA in Non-typeable Haemophilus influenzae Modulates Antibiotic Resistance and Has a Strong Impact on Its Interplay with the Host Airways. Front Cell Infect Microbiol. 2017. DOI: 10.3389/fcimb.2017.00266.
– Martínez-Díaz RA*, Ponce-Gordo F*, Rodríguez-Arce I, del Martínez-Herrero MC, González FG, Molina-López RÁ, Gómez-Muñoz MT. Trichomonas gypaetinii n. sp., a new trichomonad from the upper gastrointestinal tract of scavenging birds of prey. Parasitol Res. 2015. DOI: 10.1007/s00436-014-4165-5.
[*These authors contributed equally to this work]
Other merits
2022-Currently Associate Proffesor – University of Barcelona (UB)
2022-2023 Advisor of Ethics Committee for Animal Experimentation – Center for Genomic Regulation – CRG (Barcelona, Spain)
2021- EMBO Short-term fellowship – Comprehensive Pneumology Center – CPC (Munich, Germany)